What Can You Expect When Taking Ozempic?
Since the FDA approved Ozempic for adults with type 2 diabetes in 2017, the drug has transformed the landscape of diabetes and weight loss medications. It was soon followed by Wegovy, and more recently, Mounjaro and Zepbound, which promise even greater health impacts.
These weight loss drugs have gained considerable attention, both in medical circles and on social media. According to a survey conducted by Everyday Health in the summer of 2023, individuals who successfully lost weight were twice as likely to have used these medications compared to those who did not.
Despite increasing awareness, many questions about these medications remain. We consulted experts to provide clarity: Dr. Beverly Tchang, an obesity medicine specialist at Weill Cornell Medicine; Erin Palinski-Wade, a registered dietitian-nutritionist in Sparta, New Jersey; and Dr. Tiffani Bell Washington, a psychiatrist and obesity medicine specialist in Boston.
1. How Do Ozempic and Other Weight Loss Drugs Work?
Ozempic is a GLP-1 agonist that mimics the hormone glucagon-like peptide 1. This hormone stimulates the pancreas to produce more insulin, aiding in blood sugar regulation. Additionally, Ozempic prevents the liver from releasing excessive sugar. GLP-1 also increases feelings of fullness, reduces appetite, and slows digestion, which helps in weight loss.
GLP-1 and GIP receptor agonists, such as Mounjaro and Zepbound, work similarly by enhancing insulin release after meals and signaling satiety to the brain.
2. Who Has Had the Most Success with Ozempic?
Since its development by Novo Nordisk in 2012, numerous studies have demonstrated Ozempic’s effectiveness in blood sugar control and weight loss. Research shows an average A1C reduction of 0.77 points over six months and significant weight loss, with participants losing an average of 14.9% of their body weight over 68 weeks.
Tirzepatide, the active ingredient in Mounjaro and Zepbound, has shown even more impressive results, with weight loss up to 20.9% at higher doses over 72 weeks.
3. Who Shouldn’t Take Ozempic?
Ozempic is not recommended for pregnant individuals, those under 18, or those with a history of diabetic retinopathy, pancreatic or kidney issues. It should also be avoided by people with a family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.
4. Should Ozempic Be Taken Long-Term?
Ozempic is typically prescribed for long-term use to manage chronic conditions like obesity and type 2 diabetes. Discontinuing the medication often results in regaining lost weight. As long as the medication is well-tolerated and recommended by your healthcare provider, it can be taken indefinitely.
5. Are There Downsides to Rapid Weight Loss with Ozempic?
Rapid weight loss can lead to nutrient deficiencies and reduced muscle mass, which can impact metabolism and overall health. It may also cause “Ozempic face,” a hollowed appearance due to fat loss, and similar effects on other body parts.
6. What Side Effects Should You Be Aware Of?
Common side effects include nausea, vomiting, constipation, diarrhea, and abdominal pain. Some individuals may experience fatigue, hair loss, and more severe gastrointestinal issues. To minimize side effects, experts recommend avoiding large or high-fat meals.
7. What Are the Long-Term Health Effects?
While Ozempic and similar drugs are relatively new, some studies suggest potential long-term risks, including gastrointestinal issues and thyroid cancer. However, these risks have not been conclusively proven in humans. Ongoing monitoring and consultation with a healthcare provider are essential.
8. How Does Ozempic Affect Mental Health?
There is evidence suggesting a link between semaglutide and depression. Monitoring for psychological symptoms is crucial, and any concerning changes should be discussed with a healthcare provider.
9. How Can You Get Ozempic Covered by Insurance?
Insurance coverage for Ozempic varies. It is often covered for type 2 diabetes treatment but may not be for weight loss. New FDA-approved weight loss drugs like Zepbound may reduce the need for off-label prescriptions.
10. What Does Ozempic Cost?
Without insurance, Ozempic costs around $935.77 per pen. Wegovy, Mounjaro, and Zepbound are similarly priced but offer savings programs to lower costs.
11. What If Insurance Doesn’t Cover Ozempic?
Ozempic offers a savings card to reduce costs for those with private or commercial insurance. Other options include checking for local savings programs or using discount services like GoodRx.
12. Are There Cheaper Alternatives?
Currently, there is no generic version of Ozempic. Compounded semaglutides are available but lack the safety assurance of branded drugs. Other GLP-1 agonists or oral anti-obesity medications may be more affordable options.
13. How Do You Use Ozempic?
Ozempic is injected once a week using a prefilled pen. It can be stored in the refrigerator before use and kept at room temperature for up to 56 days after opening.
14. How Does Mounjaro Compare to Ozempic?
Mounjaro has shown superior results in weight loss and A1C reduction compared to Ozempic. However, Ozempic is FDA-approved to reduce the risk of heart attack and stroke in type 2 diabetes patients, while Mounjaro is not.
15. What Happens When You Stop Taking Ozempic?
Stopping Ozempic generally leads to weight regain due to the chronic nature of obesity. Continuing healthy lifestyle choices can help mitigate rebound weight gain.
Conclusion
Ozempic and similar medications offer significant benefits for managing diabetes and supporting weight loss. Consultation with healthcare providers is crucial to determine the best treatment plan and monitor for potential side effects.